Afaik, whenever an Activitypub instance has defederated from another it has always had to do with some combination of bad user behavior, poor moderation, and/or spam. Are the various instance admins who have decided to preemptively block threads.net simply convinced that these traits will be inevitable with it? Is it more of a symbolic move, because we all hate Meta? Or is the idea to just maintain a barrier (albeit a porous one) between us and the part of the Internet inhabited by our chuddy relatives?
(For my part, I’m working on setting up my own Lemmy and/or Pixelfed instance(s) and I do not currently intend to defederate.)
You shouldn’t underestimate it either. Even if this isn’t their intention now, it’s something they could easily do whenever they feel like it, and do you really trust Meta to have that power?