Fun fact! Cuba has a vaccine for lung cancer - yes, it works and has been independently verified. No, you can’t have it because embargo.
EDIT: vaccine here isn’t actually what I thought. In this case it is a treatment to be used for certain kinds of lung cancer, not a preventative measure as we are used to thinking of Vaccine. Thanks to the comment below for going through it and pushing me to do proper research.
While my initial take was a glib link to a wikipedia page and not thoroughly researched, I do sill believe that the embargo has directly caused this treatment to come to market in the west as the levels of cooperation are non-existent. It has been used for 7 years in Cuba but is only now entering Stage 3 trials in the US.
Slight correction on that vaccine, the FDA doesn’t authorize any drug for sale in the US that hasn’t passed it’s rigorous trials and gone through its approval process. It’s currently being tested and has more trials ongoing right now. FDA will be able to approve it for sale if it passes its trials.
Also the word cancer vaccine kind of implies cure to some, but it’s not by any means:
“MST was 10.83 months for vaccinated vs. 8.86 months for non-vaccinated. In the Phase III trial, the 5-year survival rate was 14.4% for vaccinated subjects vs. 7.9% for controls.”
So it might be a useful tool but just don’t want to get hopes up unnecessarily. People who’s immune system reacted to the vaccine the strongest did best, so current trials are focused on combining it with an immune checkpoint inhibitor drug to increase the immune response even more hopefully (and those drugs are already being used by themselves in cancer). These drugs block “checkpoints” in the immune system that would normally stop it from attacking things like yourself, which we kind of want it to do in cancer.
Not saying I support an embargo in Cuba, I don’t, just don’t want this comment to be inadvertently read as “Cuba has had the cure to lung cancer this whole time and you’re not allowed to have it!” which isn’t true.
I mean, it’s still true that Cuba has likely made significant advances in the cancer medicine, but it hasn’t passed the standards of the FDA yet. And it’s still true that the embargo between Cuba and the US is upheld to this day by politicians despite the potential good that could come from opening up trade again.
The first comment to me reads as more just overly enthusiastic, more than explicitly bad faith to me.
Vaccine does not mean cure. We did not have a Covid cure either. And much like the covid vaccine isn’t 100% effective, neither is this. However, it is proving effective, especially in combination with other drugs and at certain stages of treatment.
Stage 4 clinical trials were concluded in Cuba in 2017. Stage 2 trials were concluded in the US in 2023. I believe, strongly, that the embargo has increased the amount of time the research has taken - cooperation is impossible during an embargo.
Even if they lift the embargo tomorrow the drug wouldn’t come on the market, however it is because of the embargo that the use in treatment has taken far, far longer than it would have otherwise.
Edit: I admit I knew less about the vaccine than I thought I did (edited my comment to reflect what I have learnt)
I agree it may have presented barriers for coordination the FDA and access to US markets. I haven’t been able to dig deep into the Cuban studies, but just because something is labeled a phase 3 or phase 4 by the investigators doesn’t necessarily mean it was done to the standards necessary for fda approval or in the correct context of current standard of care treatments in the US or who knows how many other issues. If it was fully ready for all markets as is and required no further investigations, and it was only the US FDA causing problems, I would expect it to have already been widely available in many other countries that don’t have embargos with Cuba, like all of Europe. Currently it’s only available in Cuba, Colombia, Bosnia and Herzegovina, Peru, and Paraguay.
Mostly though I didn’t want someone to accidentally misread this and think it meant cure. I realize you did not say that, but it’s just a common misreading I’ve noticed people make of the term cancer vaccines when they’ve been mentioned in popular media. Didn’t want someone to drag their poor dying relative off to Paraguay thinking they’re getting cured.
I agree the Cuban embargo is ridiculous, should be stopped, and is hurting both countries with no benefit to anyone (other than keeping a certain segment of voters in Florida happy).
While Europe does not have an embargo, up until 2016 the EU and Cuba basically had 0 relationship. The EU created “The Common Position” in 1996 which was “to encourage a process of transition to a pluralist democracy” in Cuba which the Cuba government rejected as meddling in their internal affairs.
Then in the 2000s there was a bigger spat where Cuba even started rejecting EU aid.
“yes, it works, and has been independently verified” makes it seem like it is 100% ready for us markets but not available. That’s not the case, and it seems you knew that.
If a treatment is developed in the EMA, there’s a level of cooperation that means drugs can come to market quickly if proven safe and even somewhat effective (Covid vaccine is an extreme example). This treatment would likely be US ready without the embargo in place.
it seems you knew that
My original comment was a glib link to a wikipedia page. I had not done the research and have edited my comment above.
I agree, I did not make that claim! And I do find it a bit weird that people are using that line of attack. But c’est la vie. I was wrong about what the treatment did, I was wrong about the level of verification it had, however we are singing from the same hymn sheet
It’s also not a vaccine in the sense it’s preventing cancer, it’s for the treatment of cancer that is already there, specifically non small cell lung cancers (though it’s being tested in other cancers that use the signaling mechanism being targeted). Not saying it’s impossible that it could prevent cancer, just that it hasn’t been tested in that way to the best of my knowledge.
There is some precedence for a vaccine like that though. The HPV vaccine for instance prevents HPV (and therefore hpv related cancers), but is also used as a treatment if an HPV related cancer develops.
Fun fact! Cuba has a vaccine for lung cancer -
yes, it works and has been independently verified. No, you can’t have it because embargo.EDIT: vaccine here isn’t actually what I thought. In this case it is a treatment to be used for certain kinds of lung cancer, not a preventative measure as we are used to thinking of Vaccine. Thanks to the comment below for going through it and pushing me to do proper research.
While my initial take was a glib link to a wikipedia page and not thoroughly researched, I do sill believe that the embargo has directly caused this treatment to come to market in the west as the levels of cooperation are non-existent. It has been used for 7 years in Cuba but is only now entering Stage 3 trials in the US.
Cuba have also became the first country to have 0 mother-child transmissions of HIV.
But the US has decided that working with Cuba to prevent hundreds of thousands of deaths each year (in the States alone) is less important than causing “economic dissatisfaction and hardship” to the Cuban people.
Slight correction on that vaccine, the FDA doesn’t authorize any drug for sale in the US that hasn’t passed it’s rigorous trials and gone through its approval process. It’s currently being tested and has more trials ongoing right now. FDA will be able to approve it for sale if it passes its trials.
https://ascopubs.org/doi/10.1200/JCO.2023.41.16_suppl.9135
Also the word cancer vaccine kind of implies cure to some, but it’s not by any means:
“MST was 10.83 months for vaccinated vs. 8.86 months for non-vaccinated. In the Phase III trial, the 5-year survival rate was 14.4% for vaccinated subjects vs. 7.9% for controls.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346887/
So it might be a useful tool but just don’t want to get hopes up unnecessarily. People who’s immune system reacted to the vaccine the strongest did best, so current trials are focused on combining it with an immune checkpoint inhibitor drug to increase the immune response even more hopefully (and those drugs are already being used by themselves in cancer). These drugs block “checkpoints” in the immune system that would normally stop it from attacking things like yourself, which we kind of want it to do in cancer.
Not saying I support an embargo in Cuba, I don’t, just don’t want this comment to be inadvertently read as “Cuba has had the cure to lung cancer this whole time and you’re not allowed to have it!” which isn’t true.
Wow this comment really unwinds the one you replied to, so much so that the original seems in bad faith
Edit op edited, and improved their comment. You don’t need to defend them, they are fine on their own
It’s almost as if people just go on lemmy and tell lies.
What’s next, socialism has been tried and didn’t quite work??
I mean, it’s still true that Cuba has likely made significant advances in the cancer medicine, but it hasn’t passed the standards of the FDA yet. And it’s still true that the embargo between Cuba and the US is upheld to this day by politicians despite the potential good that could come from opening up trade again.
The first comment to me reads as more just overly enthusiastic, more than explicitly bad faith to me.
deleted by creator
Definitely wasn’t bad faith and I do stand by it.
Vaccine does not mean cure. We did not have a Covid cure either. And much like the covid vaccine isn’t 100% effective, neither is this. However, it is proving effective, especially in combination with other drugs and at certain stages of treatment.
Stage 4 clinical trials were concluded in Cuba in 2017. Stage 2 trials were concluded in the US in 2023. I believe, strongly, that the embargo has increased the amount of time the research has taken - cooperation is impossible during an embargo.
Even if they lift the embargo tomorrow the drug wouldn’t come on the market, however it is because of the embargo that the use in treatment has taken far, far longer than it would have otherwise.
Edit: I admit I knew less about the vaccine than I thought I did (edited my comment to reflect what I have learnt)
I agree it may have presented barriers for coordination the FDA and access to US markets. I haven’t been able to dig deep into the Cuban studies, but just because something is labeled a phase 3 or phase 4 by the investigators doesn’t necessarily mean it was done to the standards necessary for fda approval or in the correct context of current standard of care treatments in the US or who knows how many other issues. If it was fully ready for all markets as is and required no further investigations, and it was only the US FDA causing problems, I would expect it to have already been widely available in many other countries that don’t have embargos with Cuba, like all of Europe. Currently it’s only available in Cuba, Colombia, Bosnia and Herzegovina, Peru, and Paraguay.
Mostly though I didn’t want someone to accidentally misread this and think it meant cure. I realize you did not say that, but it’s just a common misreading I’ve noticed people make of the term cancer vaccines when they’ve been mentioned in popular media. Didn’t want someone to drag their poor dying relative off to Paraguay thinking they’re getting cured.
I agree the Cuban embargo is ridiculous, should be stopped, and is hurting both countries with no benefit to anyone (other than keeping a certain segment of voters in Florida happy).
While Europe does not have an embargo, up until 2016 the EU and Cuba basically had 0 relationship. The EU created “The Common Position” in 1996 which was “to encourage a process of transition to a pluralist democracy” in Cuba which the Cuba government rejected as meddling in their internal affairs.
Then in the 2000s there was a bigger spat where Cuba even started rejecting EU aid.
But since 2017 they’ve actually really warmed relations so this is a super good point!
Thank you for kicking off these research dives with your comments.
“yes, it works, and has been independently verified” makes it seem like it is 100% ready for us markets but not available. That’s not the case, and it seems you knew that.
How would that be possible during an embargo?
If a treatment is developed in the EMA, there’s a level of cooperation that means drugs can come to market quickly if proven safe and even somewhat effective (Covid vaccine is an extreme example). This treatment would likely be US ready without the embargo in place.
My original comment was a glib link to a wikipedia page. I had not done the research and have edited my comment above.
Your last sentence here would change the sentiment of your original comment in a positive way. I encourage an edit.
Oh yeah, already edited.
Reuters is bad faith?
The incomplete characterization that the drug was READY for us markets.
It is not fda approved.
Edit After discussion, the op elected to make the seen edits in their comment. I’d refer you to them.
@astreus never made that claim.
I agree, I did not make that claim! And I do find it a bit weird that people are using that line of attack. But c’est la vie. I was wrong about what the treatment did, I was wrong about the level of verification it had, however we are singing from the same hymn sheet
This has already been discussed and op met my edit request. You aren’t part of this.
For the sake of transparency, I edited before you suggested I did - hence my comment “I had not done the research and have edited my comment above.” 😉
My edit request was met. No comment on order of operations.
Sounds more like just just being I’ll informed, don’t see much reason to assume bad faith.
Thank for you adding some incredibly well summarized context.
Cigarette industry would be all over a lung cancer vaccine
It’s also not a vaccine in the sense it’s preventing cancer, it’s for the treatment of cancer that is already there, specifically non small cell lung cancers (though it’s being tested in other cancers that use the signaling mechanism being targeted). Not saying it’s impossible that it could prevent cancer, just that it hasn’t been tested in that way to the best of my knowledge.
There is some precedence for a vaccine like that though. The HPV vaccine for instance prevents HPV (and therefore hpv related cancers), but is also used as a treatment if an HPV related cancer develops.
its* rigorous trials.
People whose* immune system.
Lol, I did my best, typed it on a cell phone.
No worries, man.
That long text only has two typos? That’s impressive!